What is the minimum dose of stem cells from cord blood needed for engraftment of a new immune system?

Answer: This is the same as asking, “what is the maximum patient size that can be transplanted with a single Cord Blood collection?” The optimal dose is about 20 million nucleated cells per kilogram of body weight. “patients who received no more than 10 million nucleated cells per kilogram had a 75 percent probability of death, whereas recipients of at least 30 million nucleated cells per kilogram had a 30 percent probability of death.”

Reference:

• Editorial by Gluckman, E. NEJM 2001;344:1860